Wierschem2004 - Electrical bursting activity in Pancreatic Islets

ABSTRACT:

This a model from the article:
Complex bursting in pancreatic islets: a potential glycolytic mechanism.
Wierschem K, Bertram R. J Theor Biol 2004 Jun 21;228(4):513-21 15178199 ,
Abstract:
The electrical activity of insulin-secreting pancreatic islets of Langerhans ischaracterized by bursts of action potentials. Most often this bursting isperiodic, but in some cases it is modulated by an underlying slower rhythm. Wesuggest that the modulatory rhythm for this complex bursting pattern is due tooscillations in glycolysis, while the bursting itself is generated by some otherslow process. To demonstrate this hypothesis, we couple a minimal model ofglycolytic oscillations to a minimal model for activity-dependent bursting inislets. We show that the combined model can reproduce several complex burstingpatterns from mouse islets published in the literature, and we illustrate howthese complex oscillations are produced through the use of a fast/slow analysis.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Wierschem K, Bertram R. () - version=1.0
The original CellML model was created by:
Ethan Choi
[e-mail]
The University of Auckland

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ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1006230006 | biostudies-other |

SECONDARY ACCESSION(S): 15178199

REPOSITORIES: biostudies-other