Nelson1995_HIV1therapy_DIVadministraion_ModelB

ABSTRACT:

This a model from the article:
Modeling defective interfering virus therapy for AIDS: conditions for DIVsurvival.
Nelson GW, Perelson AS. Math Biosci 1995 Feb;125(2):127-53 7881191 ,
Abstract:
The administration of a genetically engineered defective interfering virus (DIV)that interferes with HIV-1 replication has been proposed as a therapy for HIV-1infection and AIDS. The proposed interfering virus, which is designed tosuperinfect HIV-1 infected cells, carries ribozymes that cleave conservedregions in HIV-1 RNA that code for the viral envelope protein. Thus DIVinfection of HIV-1 infected cells should reduce or eliminate viral production bythese cells. The success of this therapeutic strategy will depend both on theintercellular interaction of DIV and HIV-1, and on the overall dynamics of virusand T cells in the body. To study these dynamical issues, we have constructed amathematical model of the interaction of HIV-1, DIV, and CD4+ cells in vivo. Theresults of both mathematical analysis and numerical simulation indicate thatsurvival of the engineered DIV purely on a peripheral blood HIV-1 infection isunlikely. However, analytical results indicate that DIV might well survive onHIV-1 infected CD4+ cells in lymphoid organs such as lymph nodes and spleen, oron other HIV-1 infected cells in these organs.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Nelson GW, Perelson AS. (1995) - version=1.0
The original CellML model was created by:
Ethan Choi
[e-mail]
The University of Auckland

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ORGANISM(S): Homo sapiens

SUBMITTER: Camille Laibe 

PROVIDER: MODEL1006230033 | biostudies-other |

SECONDARY ACCESSION(S): 7881191

REPOSITORIES: biostudies-other