Weinstein2000_OMCD

ABSTRACT:

This a model from the article:
A mathematical model of the outer medullary collecting duct of the rat.
Weinstein AM. Am J Physiol Renal Physiol 2000 Jul;279(1):F24-45 10894785 ,
Abstract:
A mathematical model of the outer medullary collecting duct (OMCD) has beendeveloped, consisting of alpha-intercalated cells and a paracellular pathway,and which includes Na(+), K(+), Cl(-), HCO(3)(-), CO(2), H(2)CO(3), phosphate,ammonia, and urea. Proton secretion across the luminal cell membrane is mediatedby both H(+)-ATPase and H-K-ATPase, with fluxes through the H-K-ATPase given bya previously developed kinetic model (Weinstein AM. Am J Physiol Renal Physiol274: F856-F867, 1998). The flux across each ATPase is substantial, and variationin abundance of either pump can be used to control OMCD proton secretion. Incomparison with the H(+)-ATPase, flux through the H-K-ATPase is relativelyinsensitive to changes in lumen pH, so as luminal acidification proceeds, protonsecretion shifts toward this pathway. Peritubular HCO(3)(-) exit is via aconductive pathway and via the Cl(-)/HCO(3)(-) exchanger, AE1. To represent AE1,a kinetic model has been developed based on transport studies obtained at 38degrees C in red blood cells. (Gasbjerg PK, Knauf PA, and Brahm J. J Gen Physiol108: 565-575, 1996; Knauf PA, Gasbjerg PK, and Brahm J. J Gen Physiol 108:577-589, 1996). Model calculations indicate that if all of the chloride entryvia AE1 recycles across a peritubular chloride channel and if this channel isanything other than highly selective for chloride, then it should conduct asubstantial fraction of the bicarbonate exit. Since both luminal membrane protonpumps are sensitive to small changes in cytosolic pH, variation in density ofeither AE1 or peritubular anion conductance can modulate OMCD proton secretoryrate. With respect to the OMCD in situ, available buffer is predicted to beabundant, including delivered HCO(3)(-) and HPO(4)(2-), as well as peritubularNH(3). Thus, buffer availability is unlikely to exert a regulatory role in totalproton secretion by this tubule segment.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Weinstein AM. (2000) - version=1.0
The original CellML model was created by:
Jonna Terkildsen
[e-mail]
The University of Auckland

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Rattus

SUBMITTER: Camille Laibe 

PROVIDER: MODEL1006230037 | biostudies-other |

SECONDARY ACCESSION(S): 10894785

REPOSITORIES: biostudies-other