Kirschner1998_Immunotherapy_Tumour

ABSTRACT:

This a model from the article:
Modeling immunotherapy of the tumor-immune interaction.
Kirschner D, Panetta JC. J Math Biol 1998 Sep;37(3):235-52 9785481 ,
Abstract:
A number of lines of evidence suggest that immunotherapy with the cytokineinterleukin-2 (IL-2) may boost the immune system to fight tumors. CD4+ T cells,the cells that orchestrate the immune response, use these cytokines as signalingmechanisms for immune-response stimulation as well as lymphocyte stimulation,growth, and differentiation. Because tumor cells begin as 'self', the immunesystem may not respond in an effective way to eradicate them. Adoptive cellularimmunotherapy can potentially restore or enhance these effects. We illustratethrough mathematical modeling the dynamics between tumor cells, immune-effectorcells, and IL-2. These efforts are able to explain both short tumor oscillationsin tumor sizes as well as long-term tumor relapse. We then explore the effectsof adoptive cellular immunotherapy on the model and describe under whatcircumstances the tumor can be eliminated.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Kirschner D, Panetta JC. (1998) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1006230038 | biostudies-other |

SECONDARY ACCESSION(S): 9785481

REPOSITORIES: biostudies-other