Wodarz2007 - Cytomegalovirus infection model with cytotoxic T lymphocyte response

ABSTRACT:

This a model from the article:
Dynamics of killer T cell inflation in viral infections.
Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 ,
Abstract:
Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response ischaracterized by a phase of expansion and contraction after which it settles ata relatively stable memory level. Recently, experimental data from mice infectedwith murine cytomegalovirus (MCMV) showed different and unusual dynamics. Afteracute infection had resolved, some antigen specific CTL started to expand overtime despite the fact that no replicative virus was detectable. This phenomenonhas been termed as "CTL memory inflation". In order to examine the dynamics ofthis system further, we developed a mathematical model analysing the impact ofinnate and adaptive immune responses. According to this model, a potentiallyimportant contributor to CTL inflation is competition between the specific CTLresponse and an innate natural killer (NK) cell response. Inflation occurs mostreadily if the NK cell response is more efficient than the CTL at reducing virusload during acute infection, but thereafter maintains a chronic virus load whichis sufficient to induce CTL proliferation. The model further suggests thatweaker NK cell mediated protection can correlate with more pronounced CTLinflation dynamics over time. We present experimental data from mice infectedwith MCMV which are consistent with the theoretical predictions. This modelprovides valuable information and may help to explain the inflation of CMVspecific CD8+T cells seen in humans as they age.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

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ORGANISM(S): Mus

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1006230052 | biostudies-other |

SECONDARY ACCESSION(S): 17251133

REPOSITORIES: biostudies-other