Inada2009_AtrioventricularNode_AtrioNodalCell

ABSTRACT:

This a model from the article:
One-dimensional mathematical model of the atrioventricular node includingatrio-nodal, nodal, and nodal-his cells.
Inada S, Hancox JC, Zhang H, Boyett MR. Biophys J 2009 Oct 21;97(8):2117-27 19843444 ,
Abstract:
Mathematical models are a repository of knowledge as well as research andteaching tools. Although action potential models have been developed for mostregions of the heart, there is no model for the atrioventricular node (AVN). Wehave developed action potential models for single atrio-nodal, nodal, andnodal-His cells. The models have the same action potential shapes andrefractoriness as observed in experiments. Using these models, together withmodels for the sinoatrial node (SAN) and atrial muscle, we have developed aone-dimensional (1D) multicellular model including the SAN and AVN. Themulticellular model has slow and fast pathways into the AVN and using it we haveanalyzed the rich behavior of the AVN. Under normal conditions, actionpotentials were initiated in the SAN center and then propagated through theatrium and AVN. The relationship between the AVN conduction time and the timingof a premature stimulus (conduction curve) is consistent with experimental data.After premature stimulation, atrioventricular nodal reentry could occur. Afterslow pathway ablation or block of the L-type Ca(2+) current, atrioventricularnodal reentry was abolished. During atrial fibrillation, the AVN limited thenumber of action potentials transmitted to the ventricle. In the absence of SANpacemaking, the inferior nodal extension acted as the pacemaker. In conclusion,we have developed what we believe is the first detailed mathematical model ofthe AVN and it shows the typical physiological and pathophysiologicalcharacteristics of the tissue. The model can be used as a tool to analyze thecomplex structure and behavior of the AVN.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Inada S, Hancox JC, Zhang H, Boyett MR. (2009) - version=1.0
The original CellML model was created by:
Penny Noble
[e-mail]
The University of Oxford

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Homo sapiens

SUBMITTER: Camille Laibe 

PROVIDER: MODEL1006230082 | biostudies-other |

SECONDARY ACCESSION(S): 19843444

REPOSITORIES: biostudies-other