Wodarz2003 - Cytotoxic T lymphocyte cross-priming

ABSTRACT:

This a model from the article:
A dynamical perspective of CTL cross-priming and regulation: implications forcancer immunology.
Wodarz D, Jansen VA. Immunol Lett 2003 May 1;86(3):213-27 12706524 ,
Abstract:
Cytotoxic T lymphocytes (CTL) responses are required to fight many diseases suchas viral infections and tumors. At the same time, they can cause disease wheninduced inappropriately. Which factors regulate CTL and decide whether theyshould remain silent or react is open to debate. The phenomenon calledcross-priming has received attention in this respect. That is, CTL expansionoccurs if antigen is recognized on the surface of professional antigenpresenting cells (APCs). This is in contrast to direct presentation whereantigen is seen on the surface of the target cells (e.g. infected cells or tumorcells). Here we introduce a mathematical model, which takes the phenomenon ofcross-priming into account. We propose a new mechanism of regulation which isimplicit in the dynamics of the CTL: According to the model, the ability of aCTL response to become established depends on the ratio of cross-presentation todirect presentation of the antigen. If this ratio is relatively high, CTLresponses are likely to become established. If this ratio is relatively low,tolerance is the likely outcome. The behavior of the model includes a parameterregion where the outcome depends on the initial conditions. We discuss ourresults with respect to the idea of self/non-self discrimination and the dangersignal hypothesis. We apply the model to study the role of CTL in cancerinitiation, cancer evolution/progression, and therapeutic vaccination againstcancers.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Wodarz D, Jansen VA. (2003) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

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ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1006230094 | biostudies-other |

SECONDARY ACCESSION(S): 12706524

REPOSITORIES: biostudies-other