Waugh2006_WoundHealing_Diabetic_ModelC

ABSTRACT:

This a model from the article:
Modeling the effects of treating diabetic wounds with engineered skinsubstitutes.
Waugh HV, Sherratt JA. Wound Repair Regen 2007 Jul-Aug;15(4):556-65 17650100 ,
Abstract:
In this paper, a novel mathematical model of wound healing in both normal anddiabetic cases is presented, focusing upon the effects of adding two currentlyavailable commercial engineered skin substitute therapies to the wound(Apligraf) and Dermagraft). Our work extends a previously developed model, whichconsiders inflammatory and repair macrophage dynamics in normal and diabeticwound healing. Here, we extend the model to include equations forplatelet-derived growth factor concentration, fibroblast density, collagendensity, and hyaluronan concentration. This enables us to examine the variationof these components in both normal and diabetic wound healing cases, and tomodel the treatment protocols of these therapies. Within the context of ourmodel, we find that the key component to successful healing in diabetic woundsis hyaluronan and that the therapies work by increasing the amount of hyaluronanavailable in the wound environment. The time-to-healing results correlate withthose observed in clinical trials and the model goes some way to establishing anunderstanding of why diabetic wounds do not heal, and how these treatmentsaffect the diabetic wound environment to promote wound closure.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Waugh HV, Sherratt JA. (2007) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Homo sapiens

SUBMITTER: Camille Laibe 

PROVIDER: MODEL1006230099 | biostudies-other |

SECONDARY ACCESSION(S): 17650100

REPOSITORIES: biostudies-other