Phillips2008_AscendingArousalSystem_SleepDeprivation

ABSTRACT:

This a model from the article:
Sleep deprivation in a quantitative physiologically based model of the ascendingarousal system.
Phillips AJ, Robinson PA. J Theor Biol 2008 Dec 21;255(4):413-23 18805427 ,
Abstract:
A physiologically based quantitative model of the human ascending arousal systemis used to study sleep deprivation after being calibrated on a small set ofexperimentally based criteria. The model includes the sleep-wake switch ofmutual inhibition between nuclei which use monoaminergic neuromodulators, andthe ventrolateral preoptic area. The system is driven by the circadian rhythmand sleep homeostasis. We use a small number of experimentally derived criteriato calibrate the model for sleep deprivation, then investigate model predictionsfor other experiments, demonstrating the scope of application. Calibration givesan improved parameter set, in which the form of the homeostatic drive is betterconstrained, and its weighting relative to the circadian drive is increased.Within the newly constrained parameter ranges, the model predicts repayment ofsleep debt consistent with experiment in both quantity and distribution,asymptoting to a maximum repayment for very long deprivations. Recovery is foundto depend on circadian phase, and the model predicts that it is most efficientto recover during normal sleeping phases of the circadian cycle, in terms of theamount of recovery sleep required. The form of the homeostatic drive suggeststhat periods of wake during recovery from sleep deprivation are phases ofrelative recovery, in the sense that the homeostatic drive continues to convergetoward baseline levels. This undermines the concept of sleep debt, and is inagreement with experimentally restricted recovery protocols. Finally, we compareour model to the two-process model, and demonstrate the power of physiologicallybased modeling by correctly predicting sleep latency times following deprivationfrom experimental data.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Phillips AJ, Robinson PA. (2008) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

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ORGANISM(S): Homo sapiens

SUBMITTER: Camille Laibe 

PROVIDER: MODEL1006230115 | biostudies-other |

SECONDARY ACCESSION(S): 18805427

REPOSITORIES: biostudies-other