Dataset Information
Wajima2009_BloodCoagulation_aPTTtest
Ontology highlight
ABSTRACT: This model is from the article:
A comprehensive model for the humoral coagulation network in humans.
Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeuticsVolume 86, Issue 3, 10 June 2009, EPub 19516255,
Abstract:
Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1107010000 | biostudies-other |
SECONDARY ACCESSION(S): 19516255
REPOSITORIES: biostudies-other
Publications
A kinetic model for simulation of blood coagulation and inhibition in the intrinsic path.
Journal of medical engineering & technology 20050301 2
A mathematical simulation pathway for the generation of thrombin has been developed with various assumptions made of kinetic rate laws and their summation for reactions involving the activation of factors VIII, IX, X and V and protein C in the formation of thrombin. The object of the computational modelling study is to stimulate the activation and inhibition of blood coagulation. The level of complexity and assumed parameters makes conclusions uncertain. However, an interesting outcome is that k ...[more]