Dataset Information

Panteleev2002_TFPImechanism_schmema1

ABSTRACT: Mikhail A. Panteleev, Veronica I. Zarnitsina & Fazoil I. Ataullakhanov. Tissue factor pathway inhibitor: a possible mechanism of action. European Journal of Biochemistry 269, 8 (2002).

We have analyzed several mathematical models that describe inhibition of the factor VIIa-tissue factor complex (VIIa-TF) by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action suggesting that only the Xa-TFPI complex is the inhibitor of the extrinsic tenase activity. However, the model based on this hypothesis could not explain well all the available experimental data. Here, we show that a good quantitative description of all experimental data could be achieved in a model that contains two more assumptions. The first assumption is based on the hypothesis originally proposed by Baugh et al. [Baugh, R.J., Broze, G.J. Jr & Krishnaswamy, S. (1998) J. Biol. Chem. 273, 4378-4386], which suggests that TFPI could inhibit the enzyme-product complex Xa-VIIa-TF. The second assumption proposes an interaction between the X-VIIa-TF complex and the factor Xa-TFPI complex. Experiments to test these hypotheses are suggested.

ORGANISM(S): Eukaryota

SUBMITTER: Lucian Smith

PROVIDER: MODEL1108260006 | biostudies-other |

SECONDARY ACCESSION(S): 11985578

REPOSITORIES: biostudies-other

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Publications

Underestimation of the true benefits of antihypertensive treatment: an assessment of some important sources of error.

Linjer E E Hansson L L

Journal of hypertension 19970301 3

The treatment of arterial hypertension is based on results from several large prospective randomized intervention trials that demonstrated significant benefits from antihypertensive therapy in terms of reduced cardiovascular morbidity and mortality, mainly from strokes, but also from myocardial infarction, congestive heart failure and other vascular or renal complications. Nonetheless, it is obvious that such studies, for a number of reasons, underestimate the true benefit of lowering elevated a ...[more]

PMID: 9468448

Publication: 1/2

Dataset Information

Panteleev2002_TFPImechanism_schmema1

Publications

Underestimation of the true benefits of antihypertensive treatment: an assessment of some important sources of error.

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