Dataset Information
Geier2011 - Integrin activation
Ontology highlight
ABSTRACT: Rule based model that integrates the available data to test the biololical hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation. This model is described in the article: Abstract: Integrin signaling regulates cell migration and plays a pivotal role in developmental processes and cancer metastasis. Integrin signaling has been studied extensively and much data is available on pathway components and interactions. Yet the data is fragmented and an integrated model is missing. We use a rule-based modeling approach to integrate available data and test biological hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation. The detailed biochemical characterization of integrin signaling provides us with measured values for most of the kinetics parameters. However, measurements are not fully accurate and the cellular concentrations of signaling proteins are largely unknown and expected to vary substantially across different cellular conditions. By sampling model behaviors over the physiologically realistic parameter range we find that the model exhibits only two different qualitative behaviors and these depend mainly on the relative protein concentrations, which offers a powerful point of control to the cell. Our study highlights the necessity to characterize model behavior not for a single parameter optimum, but to identify parameter sets that characterize different signaling modes. This model is hosted on BioModels Database and identifiedby: MODEL1208280001 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resourcefor published quantitative kinetic models . To the extent possible under law, all copyright and related orneighbouring rights to this encoded model have been dedicated to the publicdomain worldwide. Please refer to CC0 Public DomainDedication for more information.
ORGANISM(S): Metazoa
SUBMITTER: Georgios Fengos
PROVIDER: MODEL1208280001 | biostudies-other |
SECONDARY ACCESSION(S): 22110576
REPOSITORIES: biostudies-other
Publications
A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation.
PloS one 20111116 11
Integrin signaling regulates cell migration and plays a pivotal role in developmental processes and cancer metastasis. Integrin signaling has been studied extensively and much data is available on pathway components and interactions. Yet the data is fragmented and an integrated model is missing. We use a rule-based modeling approach to integrate available data and test biological hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation. The detailed biochemical characterizat ...[more]
