Dataset Information
Mol2013 - Immune Signal Transduction in Leishmaniasis
Ontology highlight
ABSTRACT: Created by The MathWorks, Inc. SimBiology tool, Version 3.3
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1308080000 | biostudies-other |
SECONDARY ACCESSION(S): 23994140
REPOSITORIES: biostudies-other
Publications
Immune signal transduction in leishmaniasis from natural to artificial systems: role of feedback loop insertion.
Biochimica et biophysica acta 20130830 1
<h4>Background</h4>Modulated immune signal (CD14-TLR and TNF) in leishmaniasis can be linked to EGFR pathway involved in wound healing, through crosstalk points. This signaling network can be further linked to a synthetic gene circuit acting as a positive feedback loop to elicit a synchronized intercellular communication among the immune cells which may contribute to a better understanding of signaling dynamics in leishmaniasis.<h4>Methods</h4>Network reconstruction with positive feedback loop, ...[more]
