Dataset Information
Pathak2013 - MAPK activation in response to various biotic stresses
Ontology highlight
ABSTRACT: MAPK activation mechanism in response to various biotic (fungal and bacterial pathogens) stress conditions in plants This model is described in the article: Abstract: Mitogen-Activated Protein Kinases (MAPKs) cascade plays an important role in regulating plant growth and development, generating cellular responses to the extracellular stimuli. MAPKs cascade mainly consist of three sub-families i.e. mitogen-activated protein kinase kinase kinase (MAPKKK), mitogen-activated protein kinase kinase (MAPKK) and mitogen activated protein kinase (MAPK), several cascades of which are activated by various abiotic and biotic stresses. In this work we have modeled the holistic molecular mechanisms essential to MAPKs activation in response to several abiotic and biotic stresses through a system biology approach and performed its simulation studies. As extent of abiotic and biotic stresses goes on increasing, the process of cell division, cell growth and cell differentiation slow down in time dependent manner. The models developed depict the combinatorial and multicomponent signaling triggered in response to several abiotic and biotic factors. These models can be used to predict behavior of cells in event of various stresses depending on their time and exposure through activation of complex signaling cascades. This model is hosted on BioModels Database and identifiedby: BIOMD0000000492 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resourcefor published quantitative kinetic models . To the extent possible under law, all copyright and related orneighbouring rights to this encoded model have been dedicated to the publicdomain worldwide. Please refer to CC0 Public DomainDedication for more information.
ORGANISM(S): Viridiplantae
SUBMITTER: Lucian Smith
PROVIDER: MODEL1308220000 | biostudies-other |
SECONDARY ACCESSION(S): 23847397
REPOSITORIES: biostudies-other
Publications
Modeling of the MAPK machinery activation in response to various abiotic and biotic stresses in plants by a system biology approach.
Bioinformation 20130525 9
Mitogen-Activated Protein Kinases (MAPKs) cascade plays an important role in regulating plant growth and development, generating cellular responses to the extracellular stimuli. MAPKs cascade mainly consist of three sub-families i.e. mitogen-activated protein kinase kinase kinase (MAPKKK), mitogen-activated protein kinase kinase (MAPKK) and mitogen activated protein kinase (MAPK), several cascades of which are activated by various abiotic and biotic stresses. In this work we have modeled the hol ...[more]
