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Rao2014 - Fatty acid beta-oxidation (reduced model)

ABSTRACT:

This represents the reduced version of the "time course model" of Van Eunen et al (2013): Biochemical competition makes fatty-acid beta-oxidation vulnerable to substrate overload. The SBML was created from that of the original model and produces identical results when a time-course of 25 mins is run in COPASI

ORGANISM(S): Rattus norvegicus

SUBMITTER: Lucian Smith

PROVIDER: MODEL1403250000 | biostudies-other |

SECONDARY ACCESSION(S): 24885656

REPOSITORIES: biostudies-other

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A model reduction method for biochemical reaction networks.

Rao Shodhan S van der Schaft Arjan A van Eunen Karen K Bakker Barbara M BM Jayawardhana Bayu B

BMC systems biology 20140503

<h4>Background</h4>In this paper we propose a model reduction method for biochemical reaction networks governed by a variety of reversible and irreversible enzyme kinetic rate laws, including reversible Michaelis-Menten and Hill kinetics. The method proceeds by a stepwise reduction in the number of complexes, defined as the left and right-hand sides of the reactions in the network. It is based on the Kron reduction of the weighted Laplacian matrix, which describes the graph structure of the comp ...[more]

PMID: 24885656

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