Dataset Information
Rao2014 - Yeast glycolysis (reduced model)
Ontology highlight
ABSTRACT: This is the reduced model corresponding to "glucose upshift" condition described in the paper "Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics" by van Eunen et al published in Plos Comput Biol, 2012.
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Shodhan Rao
PROVIDER: MODEL1403250002 | biostudies-other |
SECONDARY ACCESSION(S): 24885656
REPOSITORIES: biostudies-other
Publications
A model reduction method for biochemical reaction networks.
BMC systems biology 20140503
<h4>Background</h4>In this paper we propose a model reduction method for biochemical reaction networks governed by a variety of reversible and irreversible enzyme kinetic rate laws, including reversible Michaelis-Menten and Hill kinetics. The method proceeds by a stepwise reduction in the number of complexes, defined as the left and right-hand sides of the reactions in the network. It is based on the Kron reduction of the weighted Laplacian matrix, which describes the graph structure of the comp ...[more]
