Dataset Information
Lee2009 - Adaptive immune response to Influenza A Virus infection
Ontology highlight
ABSTRACT:
ORGANISM(S): Alphainfluenzavirus
SUBMITTER: Alain Leblanc
PROVIDER: MODEL1406230000 | biostudies-other |
SECONDARY ACCESSION(S): 19439465
REPOSITORIES: biostudies-other
Publications
Simulation and prediction of the adaptive immune response to influenza A virus infection.
Journal of virology 20090513 14
The cellular immune response to primary influenza virus infection is complex, involving multiple cell types and anatomical compartments, and is difficult to measure directly. Here we develop a two-compartment model that quantifies the interplay between viral replication and adaptive immunity. The fidelity of the model is demonstrated by accurately confirming the role of CD4 help for antibody persistence and the consequences of immune depletion experiments. The model predicts that drugs to limit ...[more]
