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Miao2014 - Dynamics and migratory pathways of virus-specific antibody-secreting cell populations

ABSTRACT: This model is from the paper available at http://www.ncbi.nlm.nih.gov/pubmed/25171166. The original model contains time-varying parameters which are describedby a smoothing spline. In this model parameters S1 and S2are placeholders for these time-varying parameters. The modelcan be explored and executed through DEDiscover, with session file available at http://tinyurl.com/mc9cl77.

SUBMITTER: Alain Leblanc 

PROVIDER: MODEL1411130000 | biostudies-other |

SECONDARY ACCESSION(S): 25171166

REPOSITORIES: biostudies-other

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Publications

Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.

Miao Hongyu H   Sangster Mark Y MY   Livingstone Alexandra M AM   Hilchey Shannon P SP   Zhang Le L   Topham David J DJ   Mosmann Tim R TR   Holden-Wiltse Jeanne J   Perelson Alan S AS   Wu Hulin H   Zand Martin S MS  

PloS one 20140829 8

The B cell response to influenza infection of the respiratory tract contributes to viral clearance and establishes profound resistance to reinfection by related viruses. Numerous studies have measured virus-specific antibody-secreting cell (ASC) frequencies in different anatomical compartments after influenza infection and provided a general picture of the kinetics of ASC formation and dispersion. However, the dynamics of ASC populations are difficult to determine experimentally and have receive  ...[more]

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