Dataset Information
Talemi2015 - Persistent telomere-associated DNA damage foci (TAF), a measure to predict cancer risks
Ontology highlight
ABSTRACT: A Robust Model of DNA Damage Dynamics.Rasgou Talemi and Schaber, 12.20.2014.
SUBMITTER: Soheil Rastgou Talemi
PROVIDER: MODEL1412200000 | biostudies-other |
SECONDARY ACCESSION(S): 26359627
REPOSITORIES: biostudies-other
Publications
Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment.
Scientific reports 20150911
Mathematical modelling has been instrumental to understand kinetics of radiation-induced DNA damage repair and associated secondary cancer risk. The widely accepted two-lesion kinetic (TLK) model assumes two kinds of double strand breaks, simple and complex ones, with different repair rates. Recently, persistent DNA damage associated with telomeres was reported as a new kind of DNA damage. We therefore extended existing versions of the TLK model by new categories of DNA damage and re-evaluated t ...[more]
