Dataset Information
Weisse2015 - Cell Growth
Ontology highlight
ABSTRACT:
SUBMITTER: Andrea Weisse
PROVIDER: MODEL1502270000 | biostudies-other |
SECONDARY ACCESSION(S): 25695966
REPOSITORIES: biostudies-other
Publications
Mechanistic links between cellular trade-offs, gene expression, and growth.
Proceedings of the National Academy of Sciences of the United States of America 20150218 9
Intracellular processes rarely work in isolation but continually interact with the rest of the cell. In microbes, for example, we now know that gene expression across the whole genome typically changes with growth rate. The mechanisms driving such global regulation, however, are not well understood. Here we consider three trade-offs that, because of limitations in levels of cellular energy, free ribosomes, and proteins, are faced by all living cells and we construct a mechanistic model that comp ...[more]
