Dataset Information
Shestov2014 - aerobic glycolysis
Ontology highlight
ABSTRACT:
SUBMITTER: Lei Huang
PROVIDER: MODEL1504010000 | biostudies-other |
SECONDARY ACCESSION(S): 25009227
REPOSITORIES: biostudies-other
Publications
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.
eLife 20140709
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and statistical simulations. We identified and confirmed a novel mode of regulation specific to aerobic glycolysis where flux t ...[more]
