Dataset Information
Jalil2015 - Atypical protein kinase C isoforms in memory maintenance (Model1)
Ontology highlight
ABSTRACT:
SUBMITTER: Sajiya Jalil
PROVIDER: MODEL1505130000 | biostudies-other |
SECONDARY ACCESSION(S): 26077687
REPOSITORIES: biostudies-other
Publications
Atypical PKCs in memory maintenance: the roles of feedback and redundancy.
Learning & memory (Cold Spring Harbor, N.Y.) 20150615 7
Memories that last a lifetime are thought to be stored, at least in part, as persistent enhancement of the strength of particular synapses. The synaptic mechanism of these persistent changes, late long-term potentiation (L-LTP), depends on the state and number of specific synaptic proteins. Synaptic proteins, however, have limited dwell times due to molecular turnover and diffusion, leading to a fundamental question: how can this transient molecular machinery store memories lasting a lifetime? B ...[more]
