Dataset Information
Ashall2009 - NFkappaB dependent transcription
Ontology highlight
ABSTRACT: Model taken from Ashall et al., Science, 2009 (http://www.sciencemag.org/content/324/5924/242.long). Contact: mike.white@manchester.ac.uk. Simulation set for continuous treatment. For pulsing treatment, set 'pulse_b' events to zero.
SUBMITTER: James Boyd
PROVIDER: MODEL1509020000 | biostudies-other |
SECONDARY ACCESSION(S): 19359585
REPOSITORIES: biostudies-other
Publications
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription.
Science (New York, N.Y.) 20090401 5924
The nuclear factor kappaB (NF-kappaB) transcription factor regulates cellular stress responses and the immune response to infection. NF-kappaB activation results in oscillations in nuclear NF-kappaB abundance. To define the function of these oscillations, we treated cells with repeated short pulses of tumor necrosis factor-alpha at various intervals to mimic pulsatile inflammatory signals. At all pulse intervals that were analyzed, we observed synchronous cycles of NF-kappaB nuclear translocatio ...[more]
