Dataset Information
Saa2016 - Mammalian methionine cycle - approximate bayesian computation
Ontology highlight
ABSTRACT: Construction of feasible and accurate kinetic models of metabolism: A Bayesian approachPedro A. Saa, Lars K. Nielsen*Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia*Corresponding authorEmail: lars.nielsen@uq.edu.auReference methionine cycle model (i.e., true model) used for parameter estimation.This model is almost entirely based on the kinetic reconstruction of Korendyaseva et al. (2008).Korendyaseva TK, Kuvatov DN, Volkov Va, Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI (2008) An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. Plos Comput Biol 4: e1000076
SUBMITTER: Pedro Saa
PROVIDER: MODEL1603150000 | biostudies-other |
SECONDARY ACCESSION(S): 27417285
REPOSITORIES: biostudies-other
Publications
Construction of feasible and accurate kinetic models of metabolism: A Bayesian approach.
Scientific reports 20160715
Kinetic models are essential to quantitatively understand and predict the behaviour of metabolic networks. Detailed and thermodynamically feasible kinetic models of metabolism are inherently difficult to formulate and fit. They have a large number of heterogeneous parameters, are non-linear and have complex interactions. Many powerful fitting strategies are ruled out by the intractability of the likelihood function. Here, we have developed a computational framework capable of fitting feasible an ...[more]
