Dataset Information
Mouse Iron Distribution - Adequate iron diet (tracer)
Ontology highlight
ABSTRACT: Dynamic model of iron distribution in mice. This model includes normal iron and radioactive labelled tracer iron species and was used for parameter estimation given the data from Lopes et al. 2010 for mice fed an adequate iron diet. Mouse Iron Distribution Dynamics
ORGANISM(S): Mus musculus
SUBMITTER: Lucian Smith
PROVIDER: MODEL1605030002 | biostudies-other |
SECONDARY ACCESSION(S): 28521769
REPOSITORIES: biostudies-other
Publications
Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient.
BMC systems biology 20170518 1
<h4>Background</h4>Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative dis ...[more]
