Dataset Information
Dikicioglu2018 - Genome-scale metabolic model of Saccharomyces cerevisiae including comprehensive iron metabolism network
Ontology highlight
ABSTRACT: This SBML representation of the yeast metabolic network is made available under the Creative Commons Attribution-Share Alike 3.0 Unported Licence (see www.creativecommons.org).
ORGANISM(S): Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
SUBMITTER: Duygu Dikicioglu
PROVIDER: MODEL1709260000 | biostudies-other |
SECONDARY ACCESSION(S): 30578666
REPOSITORIES: biostudies-other
Publications
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.
Molecular cell 20060701 2
Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, as they are important not only for carbon metabolism but also are shown here to supply the acetyl-CoA for histone acetylation by histone acetyltransferases (HATs). acs2-Ts mutants exhibit global histone deacetylation, transcriptional defects, and synthetic growth defects with HAT mutants at high temperatures. In glycerol with ethanol, Acs1p is an alternate ...[more]
