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IRP1443REG - Ralstonia solanacearum GMI1000 Virulence regulatory network

ABSTRACT: We reconstructed the Virulence Regulatory Network (VRN) of R. solanacearum strain GMI1000 by collecting bibliographical information based on genetic and genomic studies, including three transcriptomic studies. The reconstructed R. solanacearum VRN comprises 712 genes including 29 genes coding for transcription factors and 34 proteins involved in signal transduction. This VRN perceives 86 signals and controls the expression of 606 genes.

SUBMITTER: Ludovic Cottret 

PROVIDER: MODEL1710170000 | biostudies-other |

SECONDARY ACCESSION(S): 29379078

REPOSITORIES: biostudies-other

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Publications

Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen.

Peyraud Rémi R   Cottret Ludovic L   Marmiesse Lucas L   Genin Stéphane S  

Nature communications 20180129 1

Robustness is a key system-level property of living organisms to maintain their functions while tolerating perturbations. We investigate here how a regulatory network controlling multiple virulence factors impacts phenotypic robustness of a bacterial plant pathogen. We reconstruct a cell-scale model of Ralstonia solanacearum connecting a genome-scale metabolic network, a virulence macromolecule network, and a virulence regulatory network, which includes 63 regulatory components. We develop in si  ...[more]

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