Dataset Information
Strasen2018 - TGFb SMAD Signalling - Dose dependent dynamics upon TGFb stimulation
Ontology highlight
ABSTRACT: This model simulates TGFb dose dependent kinetics of The SMADs. TGFb ligand dose applied are 1pM, 2.5pM, 5pM, 25pM, and 100pM as explained in the manuscript.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1712050001 | biostudies-other |
SECONDARY ACCESSION(S): 29371237
REPOSITORIES: biostudies-other
Publications
Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
Molecular systems biology 20180125 1
The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis, and regeneration. Alterations in the cellular response to TGFβ are involved in severe human diseases. To understand how cells encode the extracellular input and transmit its information to elicit appropriate responses, we acquired quantitative time-resolved measurements of pathway activation at the single-cell level. We established dynamic time warping to quantitatively compare signaling dyna ...[more]
