Dataset Information
Bekkar2018 - PPARA regulation in atherosclerosis
Ontology highlight
ABSTRACT:
SUBMITTER: Rahuman S Malik-Sheriff
PROVIDER: MODEL1712240001 | biostudies-other |
SECONDARY ACCESSION(S): 29688381
REPOSITORIES: biostudies-other
Publications
The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.
The Journal of biological chemistry 20121208 4
A persistent, low-grade inflammation accompanies many chronic diseases that are promoted by physical inactivity and improved by exercise. The beneficial effects of exercise are mediated in large part by peroxisome proliferator-activated receptor γ coactivator (PGC) 1α, whereas its loss correlates with propagation of local and systemic inflammatory markers. We examined the influence of PGC-1α and the related PGC-1β on inflammatory cytokines upon stimulation of muscle cells with TNFα, Toll-like re ...[more]