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Bekkar2018 - IL1B secretion and regulation in atherosclerosis

ABSTRACT:

This network was obtained by combining (with an OR logical operator) the following list of IL1B_secretion activators:TXNIP AND IL1B - reference in pubmed:23747245IL1B AND hydrogen_peroxide - reference in pubmed:20023662NLRP3_PYCARD_CASP1_complex AND IL1B AND cholesterol_crystal - reference in pubmed:23747245IL1B AND NLRP3 AND hydrogen_peroxide - reference in pubmed:20023662IL1B AND oxLDL AND TLR4 - reference in pubmed:23812099IL1B AND glucose - reference in pubmed:20023662IL1B AND IL1B_secretion - reference in pubmed:23747245IL1B AND CASP8 - reference in pubmed:22365665NLRP3_PYCARD_CASP1_complex AND NFE2L2 AND IL1B - reference in pubmed:23747245PYCARD AND IL1B AND hydrogen_peroxide - reference in pubmed:20023662IL1B AND NLRP3 AND glucose - reference in pubmed:20023662NFE2L2 AND IL1B - reference in pubmed:23747245IL1B AND mitochondrial_respiratory_chain_complex_I - reference in pubmed:21124315TXNIP AND IL1B AND glucose - reference in pubmed:20023662IL1B AND oxLDL AND CD36 - reference in pubmed:23812099IL1B AND ripoptosome - reference in pubmed:22365665NLRP3_PYCARD_CASP1_complex AND IL1B - reference in pubmed:23747245

SUBMITTER: Rahuman S Malik-Sheriff 

PROVIDER: MODEL1712240002 | biostudies-other |

SECONDARY ACCESSION(S): 29688381

REPOSITORIES: biostudies-other

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Publications

A role for mitochondria in NLRP3 inflammasome activation.

Zhou Rongbin R   Yazdi Amir S AS   Menu Philippe P   Tschopp Jürg J  

Nature 20101201 7329

An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host 'danger', including infection and metabolic dysregulation. Previous studies suggested that NLRP3 inflammasome activity is negatively regulated by autophagy and positively regulated by reactive oxygen species (ROS) derived from an uncharacterized organelle. Here we show that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn act  ...[more]

PMID: 21124315

Publication: 1/6

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