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Bekkar2018 - MAPK1-3 regulation in atherosclerosis

ABSTRACT:

This network was obtained by combining (with an OR logical operator) the following list of MAPK1_3 activators:PDGFRB - reference in pubmed:19742316 PDGFB AND (NOT glyoxal) - reference in pubmed:17504976PARP1 - reference in pubmed:23770291LEP - reference in pubmed:9815153PDGFB AND (NOT methylglyoxal) - reference in pubmed:17504976oxLDL - reference in pubmed:19176597IL1B_secretion - reference in pubmed:19727662

SUBMITTER: Rahuman S Malik-Sheriff 

PROVIDER: MODEL1712240003 | biostudies-other |

SECONDARY ACCESSION(S): 29688381

REPOSITORIES: biostudies-other

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Publications

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.

Zhou Li L   Takayama Yoshiharu Y   Boucher Philippe P   Tallquist Michelle D MD   Herz Joachim J  

PloS one 20090909 9

<h4>Background</h4>Low density lipoprotein receptor-related protein 1 (LRP1) protects against atherosclerosis by regulating the activation of platelet-derived growth factor receptor beta (PDGFRbeta) in vascular smooth muscle cells (SMCs). Activated PDGFRbeta undergoes tyrosine phosphorylation and subsequently interacts with various signaling molecules, including phosphatidylinositol 3-kinase (PI3K), which binds to the phosphorylated tyrosine 739/750 residues in mice, and thus regulates actin pol  ...[more]

PMID: 19742316

Publication: 1/7

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