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Lee2017 - Paracetamol first-pass metabolism PK model

ABSTRACT: Authors developed a microfluidic gut-liver co-culture chip that aims to reproduce the first-pass metabolism of oral drugs. The study suggests the possibility of reproducing the human PK profile on a chip, contributing to accurate prediction of pharmacological effect of drugs.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1803050002 | biostudies-other |

SECONDARY ACCESSION(S): 29116458

REPOSITORIES: biostudies-other

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3D gut-liver chip with a PK model for prediction of first-pass metabolism.

Lee Dong Wook DW   Ha Sang Keun SK   Choi Inwook I   Sung Jong Hwan JH  

Biomedical microdevices 20171107 4

Accurate prediction of first-pass metabolism is essential for improving the time and cost efficiency of drug development process. Here, we have developed a microfluidic gut-liver co-culture chip that aims to reproduce the first-pass metabolism of oral drugs. This chip consists of two separate layers for gut (Caco-2) and liver (HepG2) cell lines, where cells can be co-cultured in both 2D and 3D forms. Both cell lines were maintained well in the chip, verified by confocal microscopy and measuremen  ...[more]

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