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Hodgson2018 - TGFbeta signalling and inflammatory response

ABSTRACT: N/A

SUBMITTER: David hodgson 

PROVIDER: MODEL1805080001 | biostudies-other |

SECONDARY ACCESSION(S): 30677026

REPOSITORIES: biostudies-other

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Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli.

Hodgson David D   Rowan Andrew D AD   Falciani Francesco F   Proctor Carole J CJ  

PLoS computational biology 20190124 1

Osteoarthritis (OA) is a degenerative condition caused by dysregulation of multiple molecular signalling pathways. Such dysregulation results in damage to cartilage, a smooth and protective tissue that enables low friction articulation of synovial joints. Matrix metalloproteinases (MMPs), especially MMP-13, are key enzymes in the cleavage of type II collagen which is a vital component for cartilage integrity. Transforming growth factor beta (TGFβ) can protect against pro-inflammatory cytokine-me  ...[more]

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