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Lo2005 - Stochastic Modeling of Blood Coagulation Initiation

ABSTRACT: Simulation results using a stochastic approach to Hockin et al. (2002) mathematical model of the blood coagulation cascade that had been previously simulated using a deterministic method.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1805160001 | biostudies-other |

SECONDARY ACCESSION(S): 16432310

REPOSITORIES: biostudies-other

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Publications

Stochastic modeling of blood coagulation initiation.

Lo Ken K   Denney William S WS   Diamond Scott L SL  

Pathophysiology of haemostasis and thrombosis 20050101 2-3

A kinetic Monte Carlo simulation was developed using the deterministic reaction network developed by the Mann laboratory for tissue-factor (TF)-initiated blood coagulation. The model predicted thrombin dynamics in recalcified whole blood (3-fold diluted) pretreated with convulxin (platelet GPVI activator) and picomolar levels of TF (0-14 pM). The model did not accurately predict coagulation times at low TF (0-0.7 pM). The simulation revealed that approximately 0.2 pM TF was the critical concentr  ...[more]

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