Dataset Information
Evans2005 - Compartmental model for antineoplastic drug topotecan in breast cancer cells
Ontology highlight
ABSTRACT: Compartment model for the antineoplastic drug topotecan. Modelling drug in its active lactone and inactive hydroxy acid forms in the medium, extracellular, cytoplasm and nucleus.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1805210001 | biostudies-other |
SECONDARY ACCESSION(S): 10.1002/acs.856
REPOSITORIES: biostudies-other
Publications
A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan.
Mathematical biosciences 20040601 2
In this paper a compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration. The activity of topotecan in defined buffers is first modelled using a linear two compartment model that then forms the basis of a cell based model for drug activity in live cell experiments. An identifiability analysis is performed before parameter estimation to ensure that the model ...[more]