Dataset Information
Lee2016 - Blood Coagulation Model
Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1806060001 | biostudies-other |
SECONDARY ACCESSION(S): 27666750
REPOSITORIES: biostudies-other
Publications
A quantitative systems pharmacology model of blood coagulation network describes in vivo biomarker changes in non-bleeding subjects.
Journal of thrombosis and haemostasis : JTH 20161201 12
Essentials Baseline coagulation activity can be detected in non-bleeding state by in vivo biomarker levels. A detailed mathematical model of coagulation was developed to describe the non-bleeding state. Optimized model described in vivo biomarkers with recombinant activated factor VII treatment. Sensitivity analysis predicted prothrombin fragment 1 + 2 and D-dimer are regulated differently.<h4>Summary</h4>Background Prothrombin fragment 1 + 2 (F<sub>1 + 2</sub> ), thrombin-antithrombin III compl ...[more]