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Xu2002 - Blood Coagulation Model of Activated Factors with Platelet Activation

ABSTRACT: System of ODEs to describe the dynamics of several activated factors of blood coagulation. Publication introduces a platelet activation term for synthesis of Xa and IIa.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1806130001 | biostudies-other |

SECONDARY ACCESSION(S): 12376045

REPOSITORIES: biostudies-other

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Dynamic model of the role of platelets in the blood coagulation system.

Xu C Q CQ   Zeng Yan Jun YJ   Gregersen Hans H  

Medical engineering & physics 20021101 9

In order to confirm which process is the most important in the blood coagulation cascade, a dynamic model of the function of platelets in blood coagulation is provided based on biochemical experiments. A series of conclusions based on qualitative analysis and mathematical simulation are drawn about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin (IIa). It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coa  ...[more]

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