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Xu2005 - Blood Coagulation Model of Activated Factors of Extrinsic Pathway and TFPI

ABSTRACT: System of ODEs to describe the behaviour of the activated factors of the extrinsic pathway of blood coagulation with the addition of the TFPI-Xa complex. Mass-action kinetics used with the only exception of factor IIa production (Michaelis-Menten rate law).

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1806130002 | biostudies-other |

SECONDARY ACCESSION(S): 15767116

REPOSITORIES: biostudies-other

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Simulation of a mathematical model of the role of the TFPI in the extrinsic pathway of coagulation.

Xu Chuanqing C   Hu Xu Xiao X   Zeng Yanjun Y   Wen Chen Yao Y  

Computers in biology and medicine 20050601 5

Blood coagulation is a complex physiological process. With the development of biochemistry and molecular biology, especially the discovery of the tissue factor pathway inhibitor (TFPI) and further research, the researches of tissue factor (TF) and TFPI have been the hot topics now. Based on this result, we provide a new concept of blood coagulation system and provide a dynamic model to describe the role of TFPI of this pathway. Through stability analysis of the equilibrium point and numerical si  ...[more]

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