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Zarnitsina1996 - Reactions of the Intrinsic Pathway of Blood Coagulation

ABSTRACT: Model listing the reactions of the intrinsic pathway as listed in Zarnitsina1996. Publication model is a spatio-termporal mathematical model of blood coagulation.Model used as the example of the numerical intrinsic pathway in Braescu et al. (2011). L. Braescu, M. Leretter, T. George, New direct inhibitors and their computed effect on the dynamics of thrombin formation in blood coagulation, in: T. F. George (Ed.), Computational Studies of New Materials II, World Scientific, 2011, 173–190. doi:10.3389/fphys.2012.00266.

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1806140001 | biostudies-other |

SECONDARY ACCESSION(S): 8948047

REPOSITORIES: biostudies-other

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A mathematical model for the spatio-temporal dynamics of intrinsic pathway of blood coagulation. I. The model description.

Zarnitsina V I VI   Pokhilko A V AV   Ataullakhanov F I FI  

Thrombosis research 19961101 4

We developed and analyzed the mathematical model of the intrinsic pathway based on the current biochemical data on the kinetics of blood coagulation individual stages. The model includes eight differential equations describing the spatio-temporal dynamics of activation of factors XI, IX, X, II, I, VIII, V, and protein C. The assembly of tenase and prothrombinase complexes is considered as a function of calcium concentration. The spatial dynamics of coagulation was analyzed for the one-dimensiona  ...[more]

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