Dataset Information
Luan2010 - Blood Coagulation Model (extension of Luan2007)
Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1806250001 | biostudies-other |
SECONDARY ACCESSION(S): 20844798
REPOSITORIES: biostudies-other
Publications
Ensembles of uncertain mathematical models can identify network response to therapeutic interventions.
Molecular bioSystems 20100916 11
The role of mechanistic modeling and systems biology in molecular medicine remains unclear. In this study, we explored whether uncertain models could be used to understand how a network responds to a therapeutic intervention. As a proof of concept, we modeled and analyzed the response of the human coagulation cascade to recombinant factor VIIa (rFVIIa) and prothrombin (fII) addition in normal and hemophilic plasma. An ensemble of parametrically uncertain human coagulation models was developed (N ...[more]