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Mitrophanov2013 - Simulation of Hockin Blood Coagulation Model under reduced temperature

ABSTRACT: Blood coagulation model using an updated Hockin2002 model. New reactions for factor X and V activation by IXa and mIIa respectively (reactions R28 and R29, parameters k43 and k44). Changes to parameters k32 and k38 (appendix not found for cited reference [Danforth 2009] so parameters from Mitrophanov2011 were used). Model introduces formula for adjusting kinetic rates for reduced temperatures.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1806250002 | biostudies-other |

SECONDARY ACCESSION(S): 23868891

REPOSITORIES: biostudies-other

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Computational analysis of the effects of reduced temperature on thrombin generation: the contributions of hypothermia to coagulopathy.

Mitrophanov Alexander Y AY   Rosendaal Frits R FR   Reifman Jaques J  

Anesthesia and analgesia 20130718 3

<h4>Background</h4>Hypothermia, which can result from tissue hypoperfusion, body exposure, and transfusion of cold resuscitation fluids, is a major factor contributing to coagulopathy of trauma and surgery. Despite considerable efforts, the mechanisms of hypothermia-induced blood coagulation impairment have not been fully understood. We introduce a kinetic modeling approach to investigate the effects of hypothermia on thrombin generation.<h4>Methods</h4>We extended a validated computational mode  ...[more]

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