Dataset Information
Mitrophanov2014 - Extended Hockin Blood Coagulation Model with additional fibrin-associated species
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1806260001 | biostudies-other |
SECONDARY ACCESSION(S): 24958246
REPOSITORIES: biostudies-other
Publications
Kinetic model facilitates analysis of fibrin generation and its modulation by clotting factors: implications for hemostasis-enhancing therapies.
Molecular bioSystems 20140701 9
Current mechanistic knowledge of protein interactions driving blood coagulation has come largely from experiments with simple synthetic systems, which only partially represent the molecular composition of human blood plasma. Here, we investigate the ability of the suggested molecular mechanisms to account for fibrin generation and degradation kinetics in diverse, physiologically relevant in vitro systems. We represented the protein interaction network responsible for thrombin generation, fibrin ...[more]
