Unknown

Dataset Information

0

Bravo2012 - Modelling blood coagulation factor Va inactivation by APC

ABSTRACT: Mathematical model of blood coagulation factor Va and Va fragment inactivation by APC, reactions with Xa and prothrombinase-prothrombin complex formation.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1807020001 | biostudies-other |

SECONDARY ACCESSION(S): 22607732

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Modeling of human factor Va inactivation by activated protein C.

Bravo Maria Cristina MC   Orfeo Thomas T   Mann Kenneth G KG   Everse Stephen J SJ  

BMC systems biology 20120520

<h4>Background</h4>Because understanding of the inventory, connectivity and dynamics of the components characterizing the process of coagulation is relatively mature, it has become an attractive target for physiochemical modeling. Such models can potentially improve the design of therapeutics. The prothrombinase complex (composed of the protease factor (F)Xa and its cofactor FVa) plays a central role in this network as the main producer of thrombin, which catalyses both the activation of platele  ...[more]

Similar Datasets

Models Bravo2012 - Modelling blood coagulation factor Va inactivation by APC
2024-09-02 | BIOMD0000000739 | BioModels
Unknown Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation.
| S-EPMC10423252 | biostudies-literature
Proteomics Self-anticoagulant sponges for whole blood auto-transfusion and its mechanism of coagulation factor inactivation
2023-07-23 | PXD044005 | Pride
Unknown Intestinal Apc-inactivation induces HSP25 dependency.
| S-EPMC9727927 | biostudies-literature
Unknown Factor XIII-A in Diseases: Role Beyond Blood Coagulation.
| S-EPMC7867190 | biostudies-literature
Unknown Structure and dynamics of zymogen human blood coagulation factor X.
| S-EPMC1301923 | biostudies-literature
Unknown Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.
| S-EPMC5072614 | biostudies-literature
Unknown Burghaus2014 - Simulating blood coagulation factor Xa inhibitors
| MODEL1807180005 | biostudies-other
Unknown A novel snake venom C-type lectin-like protein modulates blood coagulation by targeting von Willebrand factor and coagulation factor IX.
| S-EPMC11450200 | biostudies-literature
Unknown Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics.
| S-EPMC8531165 | biostudies-literature