Dataset Information
Brummel-Ziedins2012 - Contribution of the PC pathway to thrombin generation
Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1807180002 | biostudies-other |
SECONDARY ACCESSION(S): 22984498
REPOSITORIES: biostudies-other
Publications
The prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation.
PloS one 20120912 9
The underlying cause of thrombosis in a large protein C (PC) deficient Vermont kindred appears to be multicausal and not explained by PC deficiency alone. We evaluated the contribution of coagulation factors to thrombin generation in this population utilizing a mathematical model that incorporates a mechanistic description of the PC pathway. Thrombin generation profiles for each individual were generated with and without the contribution of the PC pathway. Parameters that describe thrombin gener ...[more]
