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Platelet PAR1 with SOCE

ABSTRACT: Mathematical model of platelet intracellular signaling network

SUBMITTER: Matthew Roberts

PROVIDER: MODEL1807190001 | biostudies-other |

SECONDARY ACCESSION(S): 25627921

REPOSITORIES: biostudies-other

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Compartmentalized calcium signaling triggers subpopulation formation upon platelet activation through PAR1.

Sveshnikova Anastasia N AN Ataullakhanov Fazoil I FI Panteleev Mikhail A MA

Molecular bioSystems 20150401 4

Blood platelets need to undergo activation to carry out their function of stopping bleeding. Different activation degrees lead to a stepped hierarchy of responses: ability to aggregate, granule release, and, in a fraction of platelets, phosphatidylserine (PS) exposure. This suggests the existence of decision-making mechanisms in the platelet intracellular signaling network. To identify and investigate them, we developed a computational model of PAR1-stimulated platelet signal transduction that i ...[more]

PMID: 25627921

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