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Makin2013 - Blood coagulation cascade model

ABSTRACT: Mathematical model of the blood coagulation system including lipid binding sites, meizothrombin, thrombomodulin, cleaved and light peptide chain Va species and Heparin.

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1807230001 | biostudies-other |

SECONDARY ACCESSION(S): 24131053

REPOSITORIES: biostudies-other

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Publications

A hybrid-system model of the coagulation cascade: simulation, sensitivity, and validation.

Makin Joseph G JG   Narayanan Srini S  

Journal of bioinformatics and computational biology 20130905 5

The process of human blood clotting involves a complex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenomena, where the former comprise the various chemical rate equations and the latter comprise both threshold-limited behaviors and binary states (presence/absence of a chemical). Whereas previous blood-clotting models used only continuous dynamics and perforce addressed only portions of the coagulation cascade, we capture both continuous and discre  ...[more]

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