Dataset Information
Nagashima2002 - Simulating blood coagulation inhibitory effects
Ontology highlight
ABSTRACT:
SUBMITTER: Lucian Smith
PROVIDER: MODEL1807230003 | biostudies-other |
SECONDARY ACCESSION(S): 12496240
REPOSITORIES: biostudies-other
Publications
Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation.
The Journal of biological chemistry 20021022 52
The present study began with mathematical modeling of how inhibitors of both factor Xa (fXa) and thrombin affect extrinsic pathway-triggered blood coagulation. Numerical simulation demonstrated a stronger inhibition of thrombin generation by a thrombin inhibitor than a fXa inhibitor, but both prolonged clot time to a similar extent when they were given an equal dissociation constant (30 nm) for interaction with their respective target enzymes. These differences were then tested by comparison wit ...[more]
