Dataset Information
Mishra2018 - enhancing sorafenib efficacy by co-target identification through quantitive modelling approach
Ontology highlight
ABSTRACT:
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL1808060001 | biostudies-other |
SECONDARY ACCESSION(S): 30136368
REPOSITORIES: biostudies-other
Publications
Identification of a co-target for enhancing efficacy of sorafenib in HCC through a quantitative modeling approach.
The FEBS journal 20180906 21
Sorafenib (SFB), a multi-kinase inhibitor, is the only approved drug for treating hepatocellular carcinoma (HCC). However, SFB shows low efficacy in many cases. HCC related mortality therefore remains to be high worldwide. SFB, a multi-kinase inhibitor is also known to modulate the redox homeostasis in cancer cells. To understand the effect of SFB on the redox status, a quantitative understanding of the system is necessary. Kinetic modeling of the relevant pathways is a useful approach for obtai ...[more]
