Dataset Information
Adams2003 - Thrombin Inhibitors
Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1808150002 | biostudies-other |
SECONDARY ACCESSION(S): 12871372
REPOSITORIES: biostudies-other
Publications
Predicting the pharmacology of thrombin inhibitors.
Journal of thrombosis and haemostasis : JTH 20030501 5
Thrombotic disorders can lead to uncontrolled thrombin generation and clot formation within the circulatory system leading to vascular thrombosis. Direct inhibitors of thrombin have been developed and tested in clinical trials for the treatment of a variety of these thrombotic disorders. The bleeding complications observed during these trials have raised questions about their clinical use. The development of a computer-based model of coagulation using the kinetic rates of individual reactions an ...[more]