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Nampala2013 - Liver enzyme elevation in HIV mono-infection

ABSTRACT: the model depicts a unique endemic equilibrium with a transcritical bifurcation when the basic reproductive number is unity.

SUBMITTER: Sarubini Kananathan 

PROVIDER: MODEL1812040002 | biostudies-other |

SECONDARY ACCESSION(S): 23291466

REPOSITORIES: biostudies-other

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Mathematical modeling of liver enzyme elevation in HIV mono-infection.

Nampala Hasifa H   Luboobi Livingstone S LS   Mugisha Joseph Y T JY   Obua Celestino C  

Mathematical biosciences 20130102 1

HIV-infected individuals are increasingly becoming susceptible to liver disease and, hence, liver-related mortality is on a rise. The presence of CD4+ in the liver and the presence of C-X-C chemokine receptor type 4 (CXCR4) on human hepatocytes provide a conducive environment for HIV invasion. In this study, a mathematical model is used to analyse the dynamics of HIV in the liver with the aim of investigating the existence of liver enzyme elevation in HIV mono-infected individuals. In the presen  ...[more]

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